Delivery method determines neonatal gut microbiota and childhood asthma risk

C-section implicated in microbial modulation

A study of 700 births, 78% vaginal and 22% c-section were assessed at birth, 1 month, at age 1 year and 6 years. The caesarean section microbial score was significantly associated with asthma risk – among caesarean section–born children, 20% of those who had a high caesarean section microbial score at 1 year of age had asthma at age 6 years, compared to only 7% of children with a low caesarean section microbial score.

They concluded that delivery by caesarean section was associated with changes in the early life gut microbiota and an increased risk of asthma at 6 years of age.

Jakob Stokholm, Jonathan Thorsen, Martin J. Blaser, Morten A. Rasmussen, Mathis Hjelmsø, Shiraz S. Delivery mode and gut microbial changes correlate with an increased risk of childhood asthma. Science Translational Medicine 11 Nov 2020: Vol. 12, Issue 569, eaax9929 DOI: 10.1126/scitranslmed. aax9929

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