Contraception linked to changes in vaginal microbiota

BV and Candida more likely to occur

This cross-sectional study was performed using three groups, the levonorgestrel intrauterine-releasing system (LNG-IUS) group (1179 subjects), copper intra uterine device (IUD) group (519 subjects), and a control group of women not using contraception (14,616 subjects) were compared. The LNG-IUS and IUD groups were further divided into less and more than two years of use.

Results show that the LNG-IUS and copper IUD interfere with the microbiota over time. Specifically, the copper IUD is associated with a higher frequency of bacterial vaginosis (14.8%) and Actinomyces species infection (10.2%) while the LNG-IUS is associated with a higher frequency of candidiasis (8.1%) and cytolysis (2.6%).

Eleuterio J Junior, Giraldo PC, Silveira Gonçalves AK, Nunes Eleuterio RM. Liquid-based cervical cytology and microbiological analyses in women using cooper intrauterine device and levonorgestrel-releasing intrauterine system. Eur J Obstet Gynecol Reprod Biol. 2020 Sep 30; 255:20-24. doi: 10.1016/j.ejogrb.2020.09.051. Epub ahead of print. PMID: 33065517.

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