The PROMAGEN Study: Weight loss and Cholesterol

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

SUMMARY

An exploratory, block-randomised, parallel, double-blind, single-centre, placebo-controlled superiority study with 220 overweight and obese adults with BMI 25-34.9. The probiotic group (110) took 50 billion Lab4P probiotics every day for six months and the placebo group (110) took an identical looking placebo. Lab4P probiotic supplementation significantly reduced bodyweight by 1.5% in the overweight and obese adults with no changes to diet or lifestyle. A greater reduction in bodyweight loss was observed in the overweight adults (1.9%), adults over 50 years old (2%) and adults with high cholesterol levels (2.5%). The levels of atherogenic small dense LDL cholesterol were significantly reduced in hypercholesterolaemic overweight and obese adults supplemented with Lab4P probiotics.

Aim

This randomised, double-blind, placebo controlled study aimed to assess the effect of 6-months supplementation with the Lab4P probiotic on body weight and well-being in healthy overweight and obese individuals.

Method

Results

Body weight, BMI and Waist Circumference

Lab4P probiotic supplementation (Group 2) resulted in significant weight loss compared to Group 1 (Fig. 1)
– A difference of -1.3kg in the total population (****P< 0.0001)
– A difference of -1.4kg in the overweight participants (****P< 0.0001)
– A difference of -1.76kg in the over 50 year olds (***P< 0.001)
– A difference of -2.1kg in the hypercholesteraemic participants (****P< 0.0001)

Significant reductions in BMI, waist circumference and waist-to-height ratio were also observed in each of the above populations.

Greater rates of weight loss were observed in the overweight participants compared to the obese (1.9% vs. 1.2% reduction) and in women compared to men (1.6 vs. 1.4% reduction).

Plasma Cholesterol levels in hypercholesteraemic participants (total cholesterol > 6.2 mmol/l)

A significant reduction of 17.6% in the plasma levels of atherogenic small dense LDL-cholesterol (sdLDL-C) was observed in hypercholesterolaemic participants taking Lab4P probiotics (Group 2a) compared to Group 1a  (*P<0.05). The plasma LDL-C levels were reduced by 6.59%.

Conclusion

Supplementation of overweight and obese adults with the Lab4P probiotic for 6 months resulted in a significant reduction in body weight in the participants without any lifestyle restrictions. In hypercholesterolaemic overweight/obese subjects, a significant reduction in the levels of highly atherogenic small dense LDL cholesterol was observed in response to the probiotic.

Study links

2016

Lactobacillus plantarum CUL66 and Cholesterol Study

Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes

2016

Lactobacillus plantarum CUL66 and Cholesterol Study

Lactobacillus plantarum CUL66 can impact cholesterol homeostasis in Caco-2 enterocytes

2017

Lab4P and Cholesterol Study

The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice (Part 2)

2020

The PROMAGEN Study: Viral pandemic link?

Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?

2020

The PROMAGEN Study: URTI Symptoms

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

2020

The PROMAGEN Study: Quality of Life

A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being

2021

The PROBE Study

Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults

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