The Ultra-marathon Endurance Study

Efficacy of Lab4 probiotics in the Marathon des Sables

SUMMARY

This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.​
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.​
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group

Aim

This study aimed to assess the effect of a 12-week probiotic supplementation on race time and extracellular heat shock protein response to a multi-day ultra-endurance exercise event.

Method

Results

Race times

  • The completion time in Group 2 (Lab4) was reduced by 5 h and 36 min compared to Group 1 (12% reduction; 2819 min in Group 1 vs. 2481 min in Group 2, Figure 1).
  • The completion time with a lower dose of probiotics (Group 3) was reduced by 4 h and 9 min compared to Group 1 (9% reduction; 2819 min in Group 1 vs. 2570 min in Group 3, Figure 2).

Extracellular heat shock protein (eHsp72)

  • No differences in eHsp72 concentration were observed between groups during the study period.
  • Conclusion

    Lab4 probiotic supplementation improved the runners’ completion time during the ultra-marathon.

    Reference

    Marshall H, Chrismas BC, Suckling CA, Roberts JD, Foster J, Taylor L. Chronic probiotic supplementation with or without glutamine does not influence the eHsp72 response to a multi-day ultra-endurance exercise event. Appl Physiol Nutr Metab 2017; 42(8): 876-883.
    Scroll to Top