The Ultra-marathon Endurance Study
Efficacy of Lab4 probiotics in the Marathon des Sables
This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group
- The completion time in Group 2 (Lab4) was reduced by 5 h and 36 min compared to Group 1 (12% reduction; 2819 min in Group 1 vs. 2481 min in Group 2, Figure 1).
- The completion time with a lower dose of probiotics (Group 3) was reduced by 4 h and 9 min compared to Group 1 (9% reduction; 2819 min in Group 1 vs. 2570 min in Group 3, Figure 2).