The Keele Study
A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function
This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group
(individual’s tendency to experience anxiety in response to the anticipation of a future threat, how individuals felt over the previous 6 weeks)
Lab4 probiotics significantly decreased ‘trait’ anxiety levels compared to Group 1, where the ‘trait’ anxiety levels increased over the course of the 6 weeks supplementation (P=0.042).
‘Continuity of attention’
(ability to focus and avoid distraction)
‘Continuity of attention’ significantly increased in response to the Lab4 supplementation and decreased in Group 1 (P=0.035).
The study showed the benefit of Lab4 probiotics for cognitive function in healthy individuals.