Running to Exhaustion Study

Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

SUMMARY

This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.​
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.​
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group

Aim

This randomised, double-blind, placebo controlled cross-over study aimed to assess the effect of Lab4 based multi-strain probiotic supplementation on gut permeability, inflammation and running performance when exercising in the hot conditions.

Method

Results

Run time to fatigue

  • Significant increase in running time to fatigue in heat was observed in the probiotic group compared to placebo (*P=0.033).
  • The runners supplemented with probiotics exercised for a longer period (37 min 44s) compared to placebo (33 min).

Intestinal permeability

  •  Lactulose:Rhamnose ratio in urine was measured as an assessment of intestinal permeability.
  • Lactulose:Rhamnose ratio was 8% lower following the probiotic supplementation compared to placebo.
  • This was associated with the reduction in circulating lipopolysaccharide concentration at pre- and post-exercise.
  • Conclusion

    Four weeks of Lab4 based multi-strain probiotic supplementation significantly increased running time to exhaustion in hot environmental conditions.

    Reference

    Shing CM et al 2014. Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. European Journal of Applied Physiology 114: 93-103
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