The Cycling Endurance Study

Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled cross-over trial

SUMMARY

This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.​
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.​
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group

Aim

This randomised, double-blind, placebo controlled study aimed to assess whether Lab4 probiotic supplementation increases the absorption and oxidation of orally ingested maltodextrin and total carbohydrates oxidation during 2 hours endurance cycling.

Method

Results

Carbohydrate oxidation

  • Significant increase in carbohydrate (CHO) oxidation in the Lab4 probiotic group compared to placebo (*P<0.05).
  • Fat oxidation

  • Significant reduction in fat oxidation in the Lab4 probiotic group compared to placebo (*P<0.05).
  • Plasma Glucose

  • Significant increase in total plasma glucose levels in the Lab4 probiotic group compared to placebo (AUC, #P=0.013).
  • Significant increase in the plasma glucose levels originated from orally ingested maltodextrin drink at 15 min of exercise in the Lab4 probiotic group compared to placebo (*P=0.01)
  • Plasma Insulin

  • Significant increase in plasma insulin levels at 30, 45 and 75 min in the Lab4 probiotic group compared to placebo (*P<0.05).
  • Significant increase in total insulin concentration in the Lab4 probiotic group compared to placebo (AUC, #P=0.04).
  • Gut symptoms

  • The incidence of gastrointestinal symptoms during cycling exercise was low in both groups, suggesting that the intensity and duration of the exercise did not lead to significant gut disturbance.
  • Conclusion

    Lab4 probiotics supplementation increases total carbohydrate oxidation, whereas fat oxidation was reduced during the endurance cycling.

    Reference

    Pugh JN et al 2020. Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled crossover trial.
    American Journal of Physiology, Endocrinology and Metabolism 318 (4): E504-E513

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