The Adult Immune Response Study

Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals

SUMMARY

This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.​
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.​
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group

Aim

This study examined the effect of a 12-week Lab4 probiotic and fructooligosaccharide (FOS, prebiotic fibre) supplementation on ex-vivo pro-inflammatory and anti-inflammatory cytokine production by peripheral blood mononuclear cells extracted from healthy volunteers.

Method

Results

In the ‘resting’ immune state:

  • Significant enhancement of production of the anti-inflammatory cytokines IL-10 and TGF-β over the 12 week period (**P<0.0001)
  • During challenge with bacterial toxin:

    • Significant decrease in production of the pro-inflammatory cytokines IL-6 and IL-1β (*P<0.01,**P<0.0001)

    Conclusion

    The consumption of Lab4 probiotics in combination with FOS alters ex vivo cytokine production demonstrating the potential immunomodulatory benefits.

    Reference

    Hepburn NJ et al. 2013. Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals. Beneficial Microbes  4(4): 313-17
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