The Adult Immune Response Study
This double-blind, placebo-controlled study examines the role of probiotic administration in the prevention of C. difficile-associated diarrhoea (CDAD) in elderly patients receiving antibiotic therapy.
Results showed that Lab4 probiotics reduced the incidence of Clostridium difficile diarrhoea in these patients.
46% of patients supplemented with Lab4 probiotics were positive for Clostridium difficile toxin compared to 78% of patients in the placebo group
In the ‘resting’ immune state:
During challenge with bacterial toxin:
- Significant decrease in production of the pro-inflammatory cytokines IL-6 and IL-1β (*P<0.01,**P<0.0001)
The consumption of Lab4 probiotics in combination with FOS alters ex vivo cytokine production demonstrating the potential immunomodulatory benefits.