Supported by 14 clinical trials

Identified and isolated in 1999 and commericalised in 2004, the Lab4 probiotics consortium contains four proprietary bacteria strains – Lactobacillus acidophilus (CUL60), Lactobacillus acidophilus (CUL21), Bifidobacterium animalis subsp. lactis (CUL34) and Bifidobacterium bifidum (CUL20).

The Lab4 probiotics blend is supported by 14 clinical trials and a number of in vitro and in-vivo studies across a wide range of conditions at doses ranging from 12.5 billion CFUs to 50 billion CFU’s per day. The conditions studied to date include C. difficile, using probiotics alongside antibiotics, irritable bowel syndrome (IBS), immunity, upper respiratory tract infection (URTI), mood and performance.

2004

The Cambridge Clostridium difficile Study

Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea

2005

The Cambridge Probiotic/Antibiotic Trial 1

Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: A double-blind, placebo-controlled pilot study

2005

The Cambridge Probiotic/Antibiotic Trial 2

Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy

2008

The Sheffield IBS Trial

Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study

2009

The Cardiff Tracking Study

Use of colony-based bacterial strain typing for tracking the fate of Lactobacillus strains during human consumption

2013

The Adult Immune Response Study

Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals

2013

The Cambridge IBS Study

Effects of probiotics on the caecal and faecal microbiota of Irritable Bowel Syndrome patients receiving antibiotics: a pilot study

2014

The Keele Study

A double blind, placebo controlled, randomised pilot trial examining the effects of probiotic administration on mood and cognitive function

2014

Running to Exhaustion Study

Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

2015

The ProChild Study

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool; a randomized controlled pilot study

2016

The Hertfordshire Study

An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention

2017

The Ultra-marathon Endurance Study

Efficacy of Lab4 probiotics in the Marathon des Sables

2017

Lab4 and Cholesterol Study

The anti-cholesterolaemic effect of a consortium of probiotics: An acute study in C57BL/6J mice (Part 1)

2017

Lab4 and Memory Improvement Study

Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats

2019

Lab4 Consortia and Neuroprotection

In vitro neuroprotective activities of two distinct probiotic consortia

2019

The Marathon Endurance Study

Four weeks of probiotic supplementation reduces GI symptoms during a marathon race

2020

The Cycling Endurance Study

Probiotic supplementation increases carbohydrate metabolism in trained male cyclists: a randomised, double-blind, placebo-controlled cross-over trial

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